For a long time, China's large infusion drug packaging has always been the world of glass bottles, and 80% to 90% of large infusions in developed countries use plastic bottles or bags. Glass bottles are not only cumbersome, but also prone to contamination during the cleaning process of the bottles and have poor sanitation. In recent years, China has also attempted to introduce large infusion bottles and bag making equipment from abroad, but encountered many difficulties in its use, and most of them were unsuccessful. One of the important reasons is that China's major infusions are dominated by generic drugs and require strict packaging costs. In 2002, Hong Kong Central Bao Group Dongguan Jiahong Machinery Manufacturing Co., Ltd. launched the BOPP infusion bottle production equipment, which has caused a huge wave in China's large infusion industry, including China's largest infusion production company Shuanghe Pharmaceutical and Sichuan Kelunda. Many large infusion companies within the company have purchased the equipment to produce BOPP bottled infusion. Greatly accelerated the process of plastic packaging in China's large infusion packaging.

Dongguan Jiahong Machinery Manufacturing Co., Ltd. is a wholly-owned subsidiary of Hong Kong Top Ring Technology Group. It is the first company to develop BOPP bottle production equipment in China and has many years of experience in developing BOPP bottles. The company's factory in Dongguan invested more than 40 million Hong Kong dollars, not only can produce a full range of BOPP bottle equipment, but also a professional mold processing plant, can support a variety of related molds, which ensures that the company can provide timely satisfaction for domestic users And thoughtful after-sales service.

According to reports, by the first half of next year, the production capacity of existing and under construction BOPP bottles will exceed 1 billion bottles. Bottles, soft plastic infusion bags and hard BOPP bottles are being formed in the world.

Chinese infusions develop rapidly

Infusion is the fastest growing drug formulation in the Chinese pharmaceutical industry. Professor Xie Baoyuan of the Division of Preparation of the Shanghai Institute of Pharmaceutical Industry, said: “The current global production volume of large infusions is about 12 billion bottles, and China’s production is 3 billion bottles, accounting for about 1/4 of the world’s total production. China is a well-known large infusion producing country. In the past 10 years, the growth rate of China's large infusion output has always remained at 10% to 15%, and the variety has also grown from 30 to 40 to the current 120 or so. Among them, 76 kinds of nutrition and therapeutic infusion medicines have reached the total amount. About 50%."

From 2000 to the first half of 2001, China completed the GMP certification for large infusion manufacturers. Large infusion production enterprises are the first pharmaceutical manufacturers in China to have passed GMP certification, which laid the foundation for the healthy development of Chinese infusions.

At present, China's large infusion production enterprises are developing towards a group. There are only four or five major infusion manufacturers in the United States, 10 in Japan, 20 in Europe, and 200 in China. This industry structure and the scale of the enterprise are undoubtedly highly competitive risks. Therefore, the large-scale infusion production enterprises are united. The wave of mergers and acquisitions is inevitable in the coming years.

Diversification of packaging

The corporate development of large infusion companies will help accelerate the progress of plastic packaging. Because unlike glass packaging, plastic infusion packaging is mostly invested by pharmaceutical companies themselves to introduce equipment, which requires considerable investment. However, the plasticization of infusion packaging is a global trend. At present, the proportion of European and American plastic infusion packaging applications as high as 70% to 90%, but for a long time, China's large infusion packaging has always been the world of glass bottles, although everyone and Shanghai Baxter and other companies to produce and use plastic infusion packaging, but the ratio does not exceed 5 %.

The most important reason for this situation is that in the past, plastic packaging production equipment and raw materials were all imported from abroad, and they were expensive and could not adapt to domestic consumer demand.

Infusion plastic packaging is mainly divided into plastic bottles and plastic bags. Plastic infusion bottles are divided into PE bottles and PP bottles; PP bottles are divided into blow-molded bottles and injection-drawn bottles. The PE bottles are all blow-molded bottles, which are also made with three-in-one machines.

Plastic infusion bags are divided into PVC soft bags and non-PVC soft bags. From 1999 to 2000, some listed companies and private companies in China invested heavily in the introduction of non-PVC infusion bags, and built the largest and most modern non-PVC soft bag infusion plant in Asia. However, similar to the production technology, they need to explore and product The cost is too high, the market has not experienced the lead-in period, and most factories are seriously under-developed. In the past, the PP bottle blowing equipment also needed to be introduced from abroad, which was expensive and restricted the use and development.

Plastic infusion bottle equipment reliability

Dongguan Jiahong Machinery Manufacturing Company launched its own BOPP infusion bottle manufacturing equipment, which has caused great repercussions in the industry. The two-step method introduced by the company has attracted the attention of large-scale infusion manufacturers, including the high degree of automation, rapid production speed, stable quality, and less than half of imported equipment used in PP bottle production equipment. Shuanghe Pharmaceutical Co., Ltd. and Kehua Chemical Co., Ltd. and other well-known large-scale infusion manufacturers favored the company. In just one year or so, Jiahong has delivered more than 40 sets of equipment.

At present, the BOPP infusion bottle production equipment produced by Jiahong has formed three series of products ranging from 2200 bottles to 4500 bottles per hour. The latest models adopt Siemens' double closed-loop control system, and the reliability and stability of the equipment have been further improved.

BOPP infusion bottle production equipment selection

Faced with the trend of infusion and packaging plastics, how do companies choose the right form of packaging? Is it plastic or plastic? Is it PE or PP? Is it PVC or non-PVC? Is it a three-in-one device or an independent packaging manufacturing system? Or is it that the selection process of Hunan Jinjian Pharmaceutical Co., Ltd. has a certain representativeness? The company's chief engineer An Maofa said: “Taking into account the problems in the production process and product costs of plastic soft bags, we decided to choose PP plastic bottles. The requirements for equipment and products are: (1) Product transparency is better, bottle wall Uniform, reasonable structure, because good transparency is a good selling point; (2) Shrinkage and deformation under 115°C, 35 minutes heat and heat sterilization conditions should be small; the bottle mouth should be flat, the inside and outside cover should be tightly matched, and the seal should be tight. Regular, easy to open the cover, the pad and the inner cover can not be punctured; (3) can be automated and continuous production, minimize manual operations, to minimize the possibility of errors and pollution; equipment as far as possible to use PLC ( Microcomputer control, man-machine operation interface and optical-mechanical integration; (4) Under the above conditions, domestic equipment and raw materials are used as much as possible to reduce project investment. In accordance with the above conditions, the results we choose are: (1) Transparency is good, the preferred injection stretch blow molding process eliminates extrusion blow molding production process and equipment; (2) to meet 115 °C, 35 minutes heat sterilization, preferred PP, exclude PE; (3) can be automated continuous production Excludes indigenous equipment blanks on the manual. Therefore, we chose Dongguan Jia-hong equipment.

Supporting equipment and raw materials are also important

Raw materials, sterilization equipment and filling equipment all have a major impact on the development of BOPP infusion bottles. Shandong Xinhua Medical Devices Co., Ltd. developed a sterilization system for the use of PP plastic infusion bottles, and developed a set of methods and experiences to deal with problems in practice, which has a strong guiding significance for new equipment manufacturers. Raw materials are another important factor that determines product performance and cost. The raw materials currently used for the production of BOPP infusion bottles are mainly from Japan, South Korea and Taiwan. Among them, the Hyosung company's PP infusion bottle has passed USP certification for its special materials. It is safe and reliable, with high transparency, low stress, easy processing and reasonable prices. It has been used with domestic equipment and has achieved good results. .

market expectation

The rapid rise of BOPP bottles is directly related to the support of national policies. The State encourages pharmaceutical companies to develop new packaging and has corresponding preferential policies on taxation. In addition, the current vicious competition among glass bottle infusion companies in China is very serious, and companies are not profitable. Therefore, they hope to turn over their packaging. All these have contributed to the sudden emergence of BOPP bottles in the field of large infusions.

Mr. Gu Weijun, deputy secretary-general of China Medical Equipment Engineering Association and director of Beijing Jiahuate Consulting Services Co., Ltd., is a senior expert in the field of large infusion packaging. He admitted that he did not pay much attention to the application of BOPP bottles in infusions a year ago. It was only from the first half of this year that he suddenly discovered that large infusion companies launched the BOPP bottle production line. He believes that the BOPP infusion bottle has great potential for development, at least a five-year development cycle.

Mr. He Ruiyun, Assistant General Manager of Anhui Shuanghe Pharmaceuticals, said: “BOPP infusion bottles have developed rapidly. When we first contacted Jiahong, their BOPP bottles were not mature enough in terms of production process, hygiene, and stability. Without reservations, we provided suggestions for improvement to Jia Hong. Now that the BOPP infusion equipment has become so mature, we are also very pleased.” Shanghai Drug Packaging and Material Testing Institute responsible for drafting and formulating BOPP bottle infusion packaging standards and Zhejiang Provincial Institute of Drug Control The two experts Cai Rong and Jin Hong believe that BOPP bottle production equipment and technology are relatively concentrated, which is conducive to the formulation and implementation of national standards. Prof. Xie was the initial advocate of the BOPP infusion bottle. He was very optimistic about the development of the BOPP bottle in China and considered it as a product that meets China's national conditions. It is a good product that the Chinese can do well and can afford. In the future, the degree of automation of the equipment should be further improved, energy consumption should be reduced, and soft infusion bottles should be further developed.


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